Cayman Chemical DebromohymenIaldIsIn 100ug
A marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 µM, respectively), blocking G2 arrest; also inhibits MEK-1 (IC50 = 881 nM), GSK3β (IC50 = 1.39 μM), Cdk5/p25 (IC50 = 9.12 μM), Brk (IC50 = 0.6 μM), and other kinases largely unrelated to DNA damage/repair and cell cycling